Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-
GN44028
CAS: 1421448-26-1
Molecular Formula: C18H15N3O2
Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro- - Names and Identifiers
Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro- - Physico-chemical Properties
| Molecular Formula | C18H15N3O2 |
| Molar Mass | 305.33 |
| Density | 1.421±0.06 g/cm3(Predicted) |
| Melting Point | 144 - 148oC |
| Boling Point | 543.7±50.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Pale Brown |
| pKa | 14.30±0.20(Predicted) |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro- - Reference Information
| biological activity | GN44028 is a potent inhibitor of hypoxia-inducible factor (HIF)-1, its IC50 value is 14 nM. GN44028 can inhibit the transcriptional activity of HIF-1α induced by hypoxia, but does not inhibit the expression of HIF-1α mRNA, the accumulation of HIF-1α protein or the heterodimerization of HIF-1α/HIF-1β. |
| Target | IC50: 14 nM (HIF-1). |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: GN44028 Visit Supplier Webpage Request for quotationCAS: 1421448-26-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GN44028 Visit Supplier Webpage Request for quotationCAS: 1421448-26-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: GN44028 Visit Supplier Webpage Request for quotationCAS: 1421448-26-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-
MMV 666693
1219086-87-9
Ethyl 2-((3r,5r,7r)-adamantan-1-yl)acetate
602261-92-7
2-(4-methoxyphenyl)-2-oxoethyl 2-(4-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
1H-Pyrazolium,2,3-dihydro-4-(methoxycarbonyl)-1,1-dimethyl-3-oxo-, inner salt
110194-72-4
11-Deoxoglycyrrhetic acid
N-[4-(aminosulfonyl)phenyl]-2-isopropoxybenzamide
MMV 666693
1219086-87-9
Ethyl 2-((3r,5r,7r)-adamantan-1-yl)acetate
602261-92-7
2-(4-methoxyphenyl)-2-oxoethyl 2-(4-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
1H-Pyrazolium,2,3-dihydro-4-(methoxycarbonyl)-1,1-dimethyl-3-oxo-, inner salt
110194-72-4
11-Deoxoglycyrrhetic acid
N-[4-(aminosulfonyl)phenyl]-2-isopropoxybenzamide